The organism infecting the creatures aboard the USG Ishimura space station is a micro-organism which infects and spreads through a host, resulting in a monstrosity. The creatures were designed by looking at subjects under the microscope and incorporating tendrils, growths and flesh based abnormalities manifested into 'life sized' humanoid creatures.
The Outer space backdrop was easily researched by looking at astrological phenomenon and solar flares, obviously the magnitude of the scope was artistically altered to provide a visual feat for a video game.
Dead Space shows cultural influence taken from films such as 'Alien', this can be seen through the ridged textures and the obvious wear and tear of the environments due to some sort of traumatic event. This (at an educated guess) was accomplished by someone very talented in the ways of photo-shop, by using many lines and shades it creates an intricate and metal-organic kind of feel, due to the narrative, the ship itself is given a eerie personified character to itself.
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